Depression is a major yet highly neglected health concern on the global level, with millions relying on antidepressant medications for relief. However, recent research has raised concerns about the potential link between prolonged antidepressant use and an increased risk of sudden cardiac death (SCD).
Understanding the Study
A comprehensive study presented at the European Heart Rhythm Association (EHRA) 2025 Congress examined the association between antidepressant use and the risk of SCD. The researchers analyzed data from Denmark, focusing on individuals aged 18-90 years. They found that individuals who had used antidepressants for 1 to 5 years exhibited a 56% higher risk of SCD compared to non-users. Those with over six years of usage faced more than double the risk.
The study also highlighted age-related variations:
- Ages 30-39: Threefold increase in SCD risk for 1 to 5 years of use; fivefold for over six years.
- Ages 50-59: Doubled risk for 1 to 5 years; quadrupled for over six years.
These findings suggest a correlation between the duration of antidepressant use and heightened SCD risk.
The Impact In India
In India, mental health issues are often underdiagnosed due to societal stigma and a lack of awareness. A study indicated that nearly 45% of adults in conflict-ridden areas experience psychological distress. However, mental health literacy remains low; for instance, only 29% of adolescents could identify depression and a mere 1.3% recognized schizophrenia.
This gap in awareness leads many individuals to remain untreated or to self-medicate, potentially prolonging the duration of antidepressant use without proper medical supervision. Given the recent findings linking extended antidepressant use to increased SCD risk, it’s imperative for doctors and psychologists to address these challenges.
Recommendations for Safer Treatment
- Regular Monitoring: Patients on long-term antidepressants should undergo routine cardiovascular assessments to detect potential risks early.
- Holistic Approaches: Incorporate holistic approach such as behavioural therapy, yoga and meditation, which have shown efficacy in managing depression.
- Public Awareness Campaigns: Launch initiatives to educate the public about mental health, emphasizing early diagnosis and reducing stigma.
- Training for Healthcare Professionals: Equip doctors and primary healthcare workers with the skills to identify depression early and discuss potential medication side effects with patients.
Conclusion
While antidepressants play a mandatory role in managing depression, the recent study highlights the need for cautious and informed use, especially concerning the duration of treatment. In India, where mental health awareness and timely diagnosis are still evolving, it’s vital to analyse the inclusion of antidepressants with potential risks. Collaborative efforts between doctors and patients can pave the way for safer and more effective mental health management in the country
